miRNA sequence and expression analysis in breast tumors 1 MicroRNA sequence and expression analysis in breast tumors by deep sequencing

نویسندگان

  • Thalia A. Farazi
  • Hugo M. Horlings
  • Jelle ten Hoeve
  • Aleksandra Mihailovic
  • Hans Halfwerk
  • Pavel Morozov
  • Miguel Brown
  • Markus Hafner
  • Fabien Reyal
  • Marieke van Kouwenhove
  • Bas Kreike
  • Daoud Sie
  • Volker Hovestadt
  • Lodewyk Wessels
  • Marc J. van de Vijver
  • Thomas Tuschl
چکیده

Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 10065, USA, Academic Medical Center, Department of Pathology, Meibergdreef 9, 1105AZ, Amsterdam, Netherlands, Division of Experimental Therapy, Department of Molecular Biology, Department of Bioinformatics and Statistics, Division of Radiation Oncology, and Central Microarray Facility, Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, Netherlands

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Potential role of hsa_circ_0003098 circular RNA in breast cancer and its association with demographic factors and lymph node metastasis

Background and Objectives: A growing amount of evidence has revealed that circular RNAs (circRNAs), covalently closed single-stranded non-coding RNAs (ncRNAs), play significant roles in initiation and progression of breast cancer (BC) through different mechanisms.  This study aims to investigate the hsa_circ_0003098 expression and its potential roles in BC, as well as the circRNA/miRNA/mRNA cro...

متن کامل

MicroRNA sequence and expression analysis in breast tumors by deep sequencing.

MicroRNAs (miRNA) regulate many genes critical for tumorigenesis. We profiled miRNAs from 11 normal breast tissues, 17 noninvasive, 151 invasive breast carcinomas, and 6 cell lines by in-house-developed barcoded Solexa sequencing. miRNAs were organized in genomic clusters representing promoter-controlled miRNA expression and sequence families representing seed sequence-dependent miRNA target re...

متن کامل

Molecular and Cellular Pathobiology MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

MicroRNAs (miRNA) regulate many genes critical for tumorigenesis. We profiled miRNAs from 11 normal breast tissues, 17 noninvasive, 151 invasive breast carcinomas, and 6 cell lines by in-house–developed barcoded Solexa sequencing. miRNAs were organized in genomic clusters representing promoter-controlled miRNA expression and sequence families representing seed sequence–dependent miRNA target re...

متن کامل

Comparison of BRCA1 Expression between Triple-Negative and Luminal Breast Tumors

Background: Previous studies have suggested that BRCA1 dysregulation has been shown to have a role in triple-negative phenotypic manifestation. However, differences of BRCA1 expression, as a tumor suppressor gene, have rarely been investigated between luminal and triple-negative breast tumors. Therefore, the present study attempted to compare the BRCA1 expression in triple-negative with lu...

متن کامل

Discovery of Novel Human Breast Cancer MicroRNAs from Deep Sequencing Data by Analysis of Pri-MicroRNA Secondary Structures

MicroRNAs (miRNAs) are key regulators of gene expression and contribute to a variety of biological processes. Abnormal miRNA expression has been reported in various diseases including pathophysiology of breast cancer, where they regulate protumorigenic processes including vascular invasiveness, estrogen receptor status, chemotherapy resistance, invasion and metastasis. The miRBase sequence data...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011